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I. Type of Articles

We accept manuscripts in the following categories as detailed below: (i) Full Length Articles; (ii) Short Communications; (iii) View & Review; (iv) Clinical Research Design and (v) Letter to the Editor.

Full Length Articles

Full length articles are reports of original research on its overall size. Maximum length is 4000 words, not including abstract, figure legends, table legends and references. These articles require a structured abstract of 250 words at most. 40 references and 5 figures OR tables are allowed. Authors should cite only the best references, since multiple citations for a single point are usually duplicative, and avoid citing non-peer reviewed articles. Additional content may be submitted and published at the editor’s discretion.

Short Communications

Short Communications are abbreviated reports, which contain no more than 1250 words (excluding references), have no abstract, only 1 table or figure and 7 references or less.

View & Review 

View and review articles are a review or an opinion statement that constists on a summary of the most relevant information on a topic. They should not exceed 5000 words, excluding references and an abstract that is at most 250 words. References should cite the most important papers on the subject (not more than 60). Up to 6 figures are allowed. Principles and Practice of Clinical Research also accepts manuscripts proposing medical hypothesis. We also encourage submission of mini-review, that is a short review with up to 1500 words to discuss concisely a novel idea.

Clinical Research Design

We encourage and accept articles reporting the methodology of well-designed trials. This type of article should have no more than 3000 words, a structured abstract and only 1 table or figure and 25 references or less. For clinical research design manuscripts, authors should make clear in the manuscript the limitations and strengths of the chosen design.

Letter to the Editor

Letter to the editor consists on brief comments regarding aspects in response to specific published articles or also to report important preliminary data. They should have a maximum of 600 words, with no more than 5 references.

II. Ethics in publishing


Principles and Practice of Clinical Research adheres to the guidelines regarding authorship set by the International Committee of Medical Journal Editors. Authors must meet all of the following criteria: (1) contributing to the conception and design, or analyzing and interpreting data; (2) drafting the article or revising it critically for important intellectual content; and (3) approving the final version to be published. Supporting the study or collecting data does not constitute authorship. Authorship based solely on position (e.g., research supervisor, department head) is not permitted.


Plagiarism clearly occurs when large portions of text are cut-and-pasted (such manuscripts would not be accepted for publication) and will not be accepted.

Conflict of interest

All authors are requested to disclose any actual or potential conflict of interest including any financial, personal or other relationships with other people or organizations within three years of beginning the submitted work that could inappropriately influence, or be perceived to influence, their work. Please download the COI form from ICMJE (link: http://www.icmje.org/conflicts-of-interest/). Each author should fill out the form and all the forms need to be submitted together in a single PDF document.

III. Submission

Please submit your manuscript and accompanying files using the website submission system. You need to create an user before and then click on new submission. Make sure you upload all the files as explained below and in the instructions to authors. If you have any questions please contact by email at ppcr-journal@institutoscala.com.br. The files that should be submitted are (i) Title page (ii) Manuscript; (iii) cover letter; (iv) figures/tables; (v) COI forms; (vi) checklist; (vii) any other supplementary files (if needed).

IV. Structure of the paper

Principles and Practice of Clinical Research Journal follows the publication format developed by the American Psychological Association. Please see this tutorial, before submitting your paper to Principles and Practice of Clinical Research: http://www.apastyle.org/learn/tutorials/basics-tutorial.aspx.

1. Title page

a) Title

Concise and informative. Avoid abbreviations and formulae whenever possible.

b) Author names and affiliations.

Present the authors' affiliation institutions (where the actual work was done) below the names and indicate all affiliations with a lower-case superscript number immediately after the author's name and in front of the appropriate institution. Provide the city and country of each affiliation.

c) Corresponding author

Clearly indicate who will handle correspondence at all stages of refereeing and publication, also post-publication. Ensure that email address is provided in addition to the complete postal address of the institution. Contact details must be kept up to date by the corresponding author.?

2. Abstract

The abstract should state concisely the purpose of the research, the principal results and major conclusions. An abstract is often presented separately from the article, so it must be able to stand alone. Authors should avoid references, citing name(s) and year(s) only when essential. Also, non-standard or uncommon abbreviations should be avoided, but if necessary they must be defined at their first mention in the abstract itself. Abstract should be generally structured as: Background/Aims, Methods, Results, Conclusions

3. Keywords

Immediately after the abstract, provide 6 keywords or less, which will be used for indexing purposes. Authors should use American spelling and avoid general and plural terms and multiple concepts (avoid, for example, 'and', 'of'). Be moderate with abbreviations: only abbreviations firmly established in the field are eligible.

4. Abbreviations

Define abbreviations that are not standard in this field in a footnote to be placed on the first page of the article. Ensure that there is a consistent pattern of abbreviations throughout the article. Superscript Arabic numerals are used for such footnotes.

5. Introduction

Present the objectives of the paper and state an adequate background, avoiding a detailed literature survey or a summary of the results.

6. Material and methods

Provide sufficient detail to allow the work to be reproduced. Methods already published should be indicated by a reference: only relevant modifications should be described.

7. Results

Results should be clear and concise.

8. Discussion

The discussion does not repeat the results of the work, but explores its significance. Frequently, a combined Results and Discussion section is appropriate. Avoid extensive citations and discussion of published literature.

9. Conclusions

The main conclusions of the paper should be presented in a short Conclusions section, which may stand alone or form a subsection of a Discussion /Results and Discussion section.

10. Appendices

If there is more than one appendix, they should be identified as A, B, etc. Formulae and equations in appendices should be given separate numbering: Eq. (A.1), Eq. (A.2), etc.; in a subsequent appendix, Eq. (B.1) and so on. Similarly for tables and figures: Table A.1; Fig. A.1, etc.

11. References

We use the reference format of APA - please see tutorial from APA: http://www.apastyle.org/learn/tutorials/basics-tutorial.aspx. Authors should cite only papers directly related to the article, avoiding exhaustive lists. APA guidelines for referencing are explained below:
- In the text, the references should appear as the first author last name followed by the date of publication. Examples: 'as determined (Doe, 2010a, 2010b; Smith and Johnson, 2015). Smith et al. (2010) have shown …'

- In the reference list, references should be organized alphabetically using the surname of first author.

- Reference should be organized as: Brunoni AR, Valiengo L, Baccaro A, Zanão TA, de Oliveira JF, Goulart A, Boggio PS, Lotufo PA, Benseñor IM, Fregni F (2013). The sertraline vs. electrical current therapy for treating depression clinical study: results from a factorial, randomized, controlled trial. JAMA Psychiatry, 70, 383-91.

Authors are welcome and encourage to use a reference management software including EndNote, Mendeley, Zotero, or any other that allows to export formatted references to the word document. All of them have the APA reference style option. If you have problems with any reference management software, please contact the source company's technical support.

12. Acknowledgements

This section cannot be included on the title page, as a footnote to the title or otherwise. In a separate section at the end of the paper, before the references, authors should list the individuals who provided help during the research.

13. Publication Language

As Principles and Practice of Clinical Research is an international journal, the official language is English. Authors who are not native English speakers are advised to seek help from native speakers or submit their work for professional copyediting before submission. There are several professional companies that offer these services. One that is recommended is http://www.bluepencilscience.com/. A manuscript that is poorly written may not be accepted or authors may be asked to seek professional help.

V. Copyrights

Principles and Practice of Clinical Research journal does not require authors to transfer copyrights; however we use the creative commons license (Creative Commons Attribution-NonCommercial-ShareAlike (CC BY-NC-SA) in articles published in the journal. Please go to https://creativecommons.org/share-your-work/licensing-types-examples/ to check for more details.

All submissions must meet the following requirements.

  • The submission has not been previously published, nor is it before another journal for consideration (or an explanation has been provided in Comments to the Editor).
  • The submission file is in OpenOffice, Microsoft Word, or RTF document file format.
  • Where available, URLs for the references have been provided.
  • The text adheres to the stylistic and bibliographic requirements outlined in the Author Guidelines.
  • References and quotations must be in APA style
  • The text is single-spaced; uses a 12-point font; employs italics, rather than underlining (except with URL addresses); and all illustrations, figures, and tables locations are indicated within the text at the appropriate points, and are submitted in separate files.
  • Upload Checklist document
  • Upload Conflict of Interest Forms one per author