Principles and Practice of Clinical Research is an international, peer-reviewed, open-access, online publication directed to clinical researchers related to all aspects of clinical trials, including conduct, design, analysis, and ethics of clinical trials. The journal also welcomes the submission of preliminary research, as it can contribute to further clinical studies. Principles and Practice of Clinical Research was created to foster the network of clinical researchers and the exchange of ideas. The mission of the journal is to provide a global platform for the dissemination of high-quality research. The journal acknowledges the obstacles to publish manuscripts in areas with less tradition in research and or with lack of resources. Thus, we aim to provide as much feedback and assistance as possible to authors from these areas to encourage these scientists to continue pursuing high-quality research. In case of rejection of a manuscript, we would provide detailed feedback and allow a resubmission if the points are addressed. In case the weaknesses are important enough to invalidate the conclusions of a clinical trial, we hope that the detailed feedback will be useful to a future clinical trial that would provide valid data. We will also welcome authors with trials with invalid results and design to submit a letter to our section lessons learned from clinical trials to provide future scientists lessons that would prevent failed clinical trials.

Open access statement

The “Principles and Practice of Clinical Research Journal” (PPCRJ) is an open-access journal without article processing or submission charges (APC). PPCRJ applies the Creative Commons Attribution (CC BY) license to the works we publish. This license lets others distribute, remix, adapt, and build upon your work, even commercially, as long as they credit you for the original creation. 
The PPCRJ has the commitment to adhere to the criteria for Transformative Journals as part of the Plan S open access initiative ().
Publisher info  

The “Principles and Practice of Clinical Research Journal” (PPCRJ) is published by the non-profit educational organization Scala Institute as an independent publisher and is also sponsored by the Laboratory of Neuromodulation directed by Prof. Fregni.
Our mission is to create a community of international leaders in clinical research with skills to make progress in treatments for human disease, and this journal is a tool to achieve that.