Principles and Practice of Clinical Research is an international, peer-reviewed, open-access, online publication directed to clinical researchers related to all aspects of clinical trials, including conduct, design, analysis, and ethics of clinical trials. The journal also welcomes the submission of preliminary research, as it can contribute to further clinical studies. Principles and Practice of Clinical Research was created to foster the network of clinical researchers and the exchange of ideas. The mission of the journal is to provide a global platform for the dissemination of high-quality research. The journal acknowledges the obstacles to publish manuscripts in areas with less tradition in research and or with lack of resources. Thus, we aim to provide as much feedback and assistance as possible to authors from these areas to encourage these scientists to continue pursuing high-quality research. In case of rejection of a manuscript, we would provide detailed feedback and allow a resubmission if the points are addressed. In case the weaknesses are important enough to invalidate the conclusions of a clinical trial, we hope that the detailed feedback will be useful to a future clinical trial that would provide valid data. We will also welcome authors with trials with invalid results and design to submit a letter to our section lessons learned from clinical trials to provide future scientists lessons that would prevent failed clinical trials.