Weight loss and mortality in people living with HIV: Systematic Review Protocol and Meta-analysis

Main Article Content

Sarah Almeida Cordeiro
https://orcid.org/0000-0003-4520-961X
Tainá Costa Pereira Lopes
https://orcid.org/0000-0002-2867-7027
Dra. Roberta Lins Gonçalves

Abstract

Introduction: At the time of the first reported cases of human immunodeficiency virus (HIV) infection, people living with HIV (PLHIV) experienced weight loss. Highly active antiretroviral therapy (HAART) has dramatically changed their weight loss condition to ideal weight, overweight, and even obesity. However, there is a percentage of PLHIV that still presents weight loss, which is an independent predictor of mortality, even on HAART. Therefore, we sought to answer whether the hospitalized PLHIV on HAART, with weight loss, have higher mortality rates compared to hospitalized PLHIV on HAART, without weight loss.
Method: This is a systematic review and meta-analysis study protocol for observational studies. A systematic literature search will be performed in the MEDLINE databases via PubMed, Embase, and LILACS, using the descriptors: HIV; highly active antiretroviral therapy; weight loss; hospitalization; malnutrition; thinness; HIV wasting syndrome; body weight and mortality. The detailed study protocol was registered in the International Prospective Registry of Systematic Reviews (PROSPERO) under the number CRD42020191246. The searching process will be carried out by two reviewers, independently, and segmented into phases: Identification, Screening, Eligibility, and Selection. To analyze the methodological quality and risk of bias, the Joanna Briggs Institute (JBI) critical assessment tool for cohort studies will be used. Heterogeneity among studies will be evaluated using the Cochran's Q test and Higgins and Thompson I² statistics. Egger and Begg tests will be used to assess publication bias. The systematic review will be conducted according to the checklist of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).
Results: It is expected to produce consistent results, with a high level of scientific evidence, related to the clinical outcomes of hospitalized PLHIV on HAART with weight loss, contributing to relevant knowledge on the subject.
Conclusion: From a public health perspective, the knowledge obtained is essential to plan and implement strategies to reduce mortality in PLHIV/AIDS, especially considering the high cost of treating PLHIV in Brazil and its increase if people are hospitalized. Thus, knowing whether hospitalized PLHIV on HAART, with weight loss, have higher mortality rates than those without weight loss, will contribute to new and relevant knowledge regarding a serious public health problem, and may guide public health care and policies.


Keywords: HIV; Highly Active Antiretroviral Therapy; Weight loss; Hospitalization; Malnutrition; Consumptive Syndrome; Mortality.

Article Details

How to Cite
Almeida Cordeiro, S., Tainá C. P. Lopes, & Roberta L. Gonçalves. (2021). Weight loss and mortality in people living with HIV: Systematic Review Protocol and Meta-analysis. Principles and Practice of Clinical Research, 7(3), 11–17. https://doi.org/10.21801/ppcrj.2021.73.2
Section
Clinical Research Design
Author Biographies

Sarah Almeida Cordeiro, Graduate Program in Health Sciences PPGCIS, Faculty of Medicine, Federal University of Amazonas, UFAM, Brazil.

Nutritionist at the National Institute of Infectious Diseases Evandro Chagas - INI/ Fiocruz, working at Centro Hospitalar Covid-19. Master's student in Health Sciences, in the area of ??infectious and parasitic diseases, at UFAM; has a Multiprofessional Residency in Health, in the Intensive Care area, by UFAM; Specialist in Clinical Nutrition from the Federal University of Rio de Janeiro - UFRJ. Preceptor of internship in the Specialization Course in Clinical Nutrition applied to Infectology at INI / Fiocruz. Member of the special working group responsible for drafting and reviewing technical scientific materials: Coronavirus (Covid-19) Practical Guide for Guidelines for Food Handlers in Fiocruz  Food Environments; and Guidance on Food and Exercise in the face of the disease pandemic caused by SARS-CoV-2 (Covid-19), from the Fiocruz Contingency Plan.

Tainá Costa Pereira Lopes , Graduate Program in Health Sciences PPGCIS, Faculty of Medicine, Federal University of Amazonas, UFAM, Brazil.

Physiotherapist graduated from the Federal University of Amazonas (UFAM). Master's student in Health Sciences - UFAM. Experience in the area of ??Pulmonary Rehabilitation in extension projects (PACE) at UFAM. Worked on an extension project in the Motor Activities Program for the Disabled (PROAMDE) with disabled people with sequelae of Stroke and Head Injury (TCE) at UFAM. He has a complementary training course in Ear Acupuncture, Clinical Chiropractic and experience in Traumato-orthopedic and Respiratory Physiotherapy.

Dra. Roberta Lins Gonçalves, Graduate Program in Health Sciences PPGCIS, Faculty of Medicine, Federal University of Amazonas, UFAM, Brazil.

Coordinator of the Strict Senso Postgraduate Program: Master's Degree in Health Sciences, Faculty of Medicine, UFAM. Scientific Director of Regional AM of ASSOBRAFIR. Graduated in Physiotherapy at the Faculty of Medical Sciences of Minas Gerais (1993), Master in Biological Sciences (Physiology and Pharmacology) at the Federal University of Minas Gerais - ICB / UFMG - (2002) CAPES 7. PhD in Biological Sciences (Physiology and Pharmacology) by UFMG (2008) CAPES 7. Specialist in Respiratory Physiotherapy (ASSOBRAFIR / COFFITO). Specialization in Teaching in Health (UFRGS). Adjunct Professor IV at the Federal University of Amazonas. Creator and Coordinator of the Physiotherapy Residency Program in Neonatal Intensive Care at UFAM (2015-2019). Coordinator of the Physiotherapy course at UFAM from 2013 to 2017. Coordinator of the research group- CNPq Functional Health directory: epidemiology, evaluation and treatment.