Julia De Conti Pelanda
Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
Ana Maria Cabal Herrera
Grupo en Malformaciones Congénitas y Perinatales (MACOS), Universidad del Valle, Cali, Colombia.
Irene de Torres Garcia
Physical Medicine and Rehabilitation Unit, Hospital Regional Universitario de Málaga, Málaga, Spain.
Karen Burken Burgess
Department of Pediatrics, University of Alabama, Tuscaloosa, Alabama, United States of America.
Flavia Engel Aduan
Breast Radiology Department, Alvo Medicina Diagnóstica, Rio de Janeiro, Rio de Janeiro, Brazil.
Angela Patricia Koo
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America.
Afaf Khaled Hamze
Cranio Oral and Maxillofacial Surgery Department, Hamad Medical Corporation, Doha, Qatar.
Andreza Lamonica
Hematological Department, Universidade de Campinas (Unicamp), Campinas, São Paulo, Brazil.
Bruno Leonardo Duarte Pereira
Cardiology Division, Military Firefighter Corp of the Federal District, Brasília, Distrito Federal, Brazil.
Camila Sirieiro Abreu
Clinical Research Coordinator, Ache Laboratórios Farmacêuticos, Garulhos, São Paulo, Brazil.
Daniel Sebastian Bustamante Soliz
Centro de Investigación, Universidade de Cuenca, Cuenca, Ecuador.
David Estiven Arboleda Prado
Unidad Central Valle del Cauca (UCEVA), Tula-Valle, Colombia.
Felipe Alves Vione
Laboratory of Pain and Neuromodulation, Hospital das Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Hadiza Theyra-Enias
Oncology Unit, Department of Radiology, Barau Dikko Teaching Hospital/Kaduna State University, Kaduna, Kaduna State, Nigeria.
Huascar Alexander Rodriguez Cuello
Hospital Robert Reid Cabral, Mission Ilac, Universidad Autónoma de Santo Domingo, Santo Domingo, Dominican Republic.
Luiza Fonseca Sales de Medeiros
Clinical Research Study Coordinator, Instituto Brasileiro de Controle do Câncer, São Paulo, São Paulo, Brazil.
Mirian Antonieta Cardenas Vargas
General Medicine, San Martin de Porres University, Lima, Lima, Peru.
Mohammed Ali Al-Hamzi
Internal Medicine, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Naglaa Mohammed Ahmed Abdelrahim Omer
Family Medicine Department, West Bay Health Center, Doha, Qatar.
Phool Iqbal
Critical Care Medicine, Hamad Medical Corporation, Doha, Qatar.
Ricardo Virginio Dos Santos
Radiologia Intervencionista, Hospital São Camilo Oncologia, São Paulo, São Paulo, Brazil.
Tiago Ernesto Reyes Castro
Cardiology Department, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America.
Yosanly Vanessa Cornelio Puello
Dirección General de Epidemiologia, Ministerio dde Salud Publica, Santo Domingo, Distrito Nacional, Domincan Republic.
Juan Manuel Linares
Department of Pediatric Surgery, Neuquén Provincial Hospital ‘Dr. Castro Rendón’, Neuquén Capital City, Argentina.
Ahmed Fouad Algendy
Clinical Pharmacy, Geriatric Department, Rumailah Hospital, Hamad Medical Corporation, Doha, Qatar.
Abstract
Background: Due to the coronavirus pandemic, the number of hospitalized individuals increased exponentially. The sudden increase in workload, the social isolation, and the fear of COVID-19 contributed to a remarkable increase of depression cases (from 20.9% to 43.2%) among healthcare workers. Although many treatments are available for depression, including pharmacotherapy, exercise, and virtual reality, response varies widely, from complete recovery to non-responders and relapsing cases. In this sense, Wii Sports™ may serve as an alternative to improve response to standard first-line therapy, since it provides an interactive environment, physical activity and incorporates playfulness.
Objective: Evaluate the effect of Wii Sports™ in treating mild and moderate cases of major depressive disorder in healthcare professionals who developed depression during the COVID-19 pandemic.
Methods: The WIRED trial is a phase II, multicenter, randomized, active-controlled, single-blinded, superiority trial with two parallel groups. The intervention group will be composed of Wii Sports™ in addition to a first-line antidepressant, while the control group will be composed of Wii™ games that do not involve physical activity in addition to a first-line antidepressant. The primary outcome is to detect a group mean difference in the 17-item Hamilton Depression Rating Scale (HAM-D17) at week twelve, while secondary outcomes include participant adherence and comparison of HAM-D17 scores at different time points.
Conclusion: To our knowledge, there is no previous literature published that targets the same population, tests the same intervention, and evaluates the same outcomes, highlighting the possible impact of the study on the psychological and psychiatric fields, regardless of its results.
Keywords: Coronavirus, COVID-19, depression, Major Depression Disorder, Wii Sports™, virtual reality, exercise.
