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Background: Spasticity is a core clinical presentation of Multiple Sclerosis, associated with disease progression, significantly
affecting patients’ and caregivers’ quality of life. Numerous clinical scales have been developed to assess the impact and
severity of spasticity in patients with Multiple Sclerosis. Yet, a consensus on the best tool still needs to be reached.
Objective: To provide an overview of the clinical scales most often used when studying spasticity in Multiple Sclerosis,
including studies utilizing these tools.
Methods: We extensively searched the MEDLINE (PubMed) database; articles published in English between November
2003 and July 2023 were included. We utilized the Cochrane’s Methods Executive tools for bias assessment. The extracted
data was synthesized to provide a comprehensive overview of the current evidence about the clinical scales used to assess
and quantify muscle spasticity in MS.
Results: The final analysis included 13 articles. Six studies focused on the assessment of spasticity scales. The remaining
articles involved interventions and observational studies. The Modified Ashworth Scale and Ashworth Scale were the most
frequently used scales (38.4
Discussion: Quantifying spasticity by clinical scales is necessary for correct grading and evaluation of treatment responses.
The studies selected for this review showed significant variability in the spasticity measure scales utilized. The most
prevalent choices were the MAS and AS, independently used or combined with other tools. A detailed rationale for the
choice of scale was absent in all of the included studies. Further research is crucial to determine the most suitable scale for
assessing spasticity in multiple sclerosis in the setting of clinical research.