Advances in Gene Therapy Treatment for Obesity: A Mini-review

Paul Warncke; Natalia Oliveira de Sa; Tássia Medeiros Feldens; Guilherme L. da Rocha; Julia Daudt de Faro Salamonde; Veronica Echavarria; Daniela Ibanez F; Anthonia Inibokun Njoku; Roberto Nishimura; Javier Grajeda; Jose Laso; Sasha Mukhija; Antonia Egert; Magdiel A. Amell Castillo; Leticia Checo; Luana Moreira; Thaila Pereira Schmidt; Marcelo  Freitas; Luciane Lie Ikeda; Ana Beatriz Pizarro

doi:10.21801/ppcrj.2023.94.7

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Published: Feb 16, 2024

Paul Warncke

Klinikum Chemnitz gGmbH, Department of Internal Medicine III, Chemnitz, Germany

Natalia Oliveira

D’Or Institute for Research and Education - IDOR-RJ, Brazil

Tássia Medeiros Feldens

Radiology, Passo Fundo, Rio Grande do Sul, Brazil

Guilherme L. da Rocha

UFPR - PPGMICS - Internal Medicine, Curitiba, PR, Brazil

Julia Daudt de Faro Salamonde

Faculdade São Leopoldo Mandic (SLM)- Campinas, Brazil

Veronica Echavarria

Private practice, Bogotá, Colombia

Daniela Ibanez F

CINSAN. Clínica Dávila, Santiago, Chile

Anthonia Inibokun Njoku

Department of Obstetrics and gynecology, Irrua Specialist Teaching Hospital, Irrua, Edo state, Nigeria

Roberto Nishimura

Department of Orthopedics, Pontifical Catholic University of Campinas Medical School, Campinas city, Brazil

Javier Grajeda

Faculty of Medicine, Universidad Francisco Marroquín, Guatemala

Jose Laso

Hospital del Trabajador, Santiago, Chile

Sasha Mukhija

Harvard Medical School, Boston, USA

Antonia Egert

CAAT, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, US

Magdiel A. Amell Castillo

Instituto de Salud Mental y Telepsicología (ISAMT)

Leticia Checo

Ophthalmology Department, Mayo Clinic Florida, USA

Luana Moreira

Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador, Brazil

Thaila Pereira Schmidt

Americas Serviços Médicos, RJ, Brazil

Marcio Carlos de Freitas

Clinica Dr. Marcio Freitas, Brazil

Luciane Lie Ikeda

Unicamp, Brazil

Ana Beatriz Pizarro

Clinical Research Center, Fundación Valle del Lili, Cali, Colombia

Abstract

Obesity is a highly prevalent global pandemic that is rapidly growing. Recent advancements in gene therapy have opened
new possibilities and targets for treating, especially monogenic forms of obesity. This mini-view identified novel preclinical
developments in obesity genetic treatment over the past five years. Novel strategies targeting single or multiple genes or
enzymes were identified as potential alternatives for existing treatment approaches. Although clinical trials for genetic
obesity treatment are yet to emerge, novel preclinical treatment approaches based on genetic traits hold promise for addressing
the obesity pandemic.

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Advances in Gene Therapy Treatment for Obesity: A Mini-review. (2024). Principles and Practice of Clinical Research, 9(4). https://doi.org/10.21801/ppcrj.2023.94.7

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Vol. 9 No. 4 (2023): Principles and Practice of Clinical Research

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View and Review

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Advances in Gene Therapy Treatment for Obesity: A Mini-review. (2024). Principles and Practice of Clinical Research, 9(4). https://doi.org/10.21801/ppcrj.2023.94.7

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