Exploring the Link Between Hepatitis A and B Vaccination and Social Support in the US Population: Insights from the NHANES 2005-2006 Cohort

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Daniel Bancovsky
Manjushree Shastry
Martina Caccamo
Omar E. Vasquez-Perez
Merce Avellanet
Kumud Chapagain
Rebecca Soares
Magali Coyoy
Hoang Nguyen
Juliana Calit
Asma Qudayr
Rintu Sharma
Cynthia L. P. de Borborema
Sebastine Oiwoh
Jorge Alave
Beatrice Dalbianco
Maria Antonieta Lopes
Ricardo E. Nunez-Rocha
Maria Magalhaes
Faiez Alsatou
Felipe Duarte
Jessica Rodriguez
Ilgin Genc
Walter Ramos
Fabricio Kleber
Patricia Rioja
Ignacio Montealegre
Isabel Cabral
Luiz Viola
Barbara Grohmann
Yoldyz Huynh
Lucas Vidoto
Arantxa Ramirez
Anny Christina Chin
Alessandra Carvalho

Abstract

Background: High social support is easily assessed and associated with a healthier lifestyle, including vaccination adherence. Similarly, immunization is a widely available public health statistic associated with healthier behaviors. However, the link between the hepatitis immunization status and social support needs to be explored.

Methods: We assessed the association between levels of social support and hepatitis immunization status using the National Health and Nutrition Examination Survey (NHANES), a cross-sectional multidisciplinary database publicly available for researchers. With 2005–2006 data, 2997 participants were included. Statistical analyses were conducted using STATA18.5v software, including the odds ratio of both univariable logistic regression and multivariable logistic regression. After adjusting for clinically relevant confounders, two distinct models were designed: 1) full immunization, and 2) incomplete immunization.

Results: Multivariable analysis revealed significantly greater odds of high social support for participants fully or partially immunized against both hepatitis A and B: 3.15 (95% CI 1.03–9.66,p=0.04) and 3.35 (95% CI 1.15–9.75,p=0.03), respectively.

Conclusion: Our findings show an association between vaccination and social support in both adjusted models. Individuals not vaccinated at all may behave differently from those willing to be, at least partially, immunized. It seems that a similar behavior that may lead to vaccination may also lead to increased social support. Therefore, our study suggests that hepatitis vaccination could perhaps be a surrogate marker for public-health-related outcomes.

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Exploring the Link Between Hepatitis A and B Vaccination and Social Support in the US Population: Insights from the NHANES 2005-2006 Cohort. (2025). Principles and Practice of Clinical Research, 11(2). https://doi.org/10.21801/ppcrj.2025.112.6
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Exploring the Link Between Hepatitis A and B Vaccination and Social Support in the US Population: Insights from the NHANES 2005-2006 Cohort. (2025). Principles and Practice of Clinical Research, 11(2). https://doi.org/10.21801/ppcrj.2025.112.6

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