Restoring Guidelines: EBM-X to Bring Critical Thinking and Humility Back to Evidence-Based Medicine

Lisbeth Martinez; Lucas Mena; Beatriz Cubilhas; Danilo Monteiro; Andre Canteri; Felipe Fregni

doi:10.21801/ppcrj.2025.112.9

Main Article PDF

Published: Oct 7, 2025

Lisbeth Martinez

Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA; Harvard T.H. Chan School of Public Health – ECPE, Principles and Practice of Clinical Research (PPCR) Program, Boston, MA, USA

Lucas Mena

Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador, BA, Brazil; Harvard T.H. Chan School of Public Health – ECPE, Principles and Practice of Clinical Research (PPCR) Program, Boston, MA, USA

Beatriz Cubilhas

Danilo Monteiro

Institute of Orthopaedics and Traumatology, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil; Harvard T.H. Chan School of Public Health – ECPE, Principles and Practice of Clinical Research (PPCR) Program, Boston, MA, USA

Andre Canteri

Postgraduate Program in Internal Medicine and Health Sciences (PPGMICS), Federal University of Paraná (UFPR), Curitiba, Brazil; Echocardiography Unit, Center for Diagnostic Medicine (CMD), Hapvida NotreDame Intermédica, Curitiba, Brazil; Harvard T.H. Chan School of Public Health – ECPE, Principles and Practice of Clinical Research (PPCR) Program, Boston, MA, USA

Felipe Fregni

Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Cambridge, MA, USA

Abstract

N/A

How to Cite

Restoring Guidelines: EBM-X to Bring Critical Thinking and Humility Back to Evidence-Based Medicine. (2025). Principles and Practice of Clinical Research, 11(2). https://doi.org/10.21801/ppcrj.2025.112.9

Issue

Vol. 11 No. 2 (2025): Principles and Practice of Clinical Research

Section

Notes from the Editors

How to Cite

Download Citation

Most read articles by the same author(s)

Augusto José Mendes, Kevin Pacheco-Barrios, Paola Gonzalez-Mego, Alma Sanchez, Felipe Fregni, Ten strategies to formulate a strong research question , Principles and Practice of Clinical Research: Vol. 6 No. 2 (2020): Principles and Practice of Clinical Research
Kevin Pacheco-Barrios, Anna Carolyna Gianlorenço, Roberto Machado, Marcos Queiroga, Huiyan Zeng, Emad Shaikh, Yiling Yang, Beatriz Nogueira, Luis Castelo-Branco, Felipe Fregni, Exercise-induced pain threshold modulation in healthy subjects: a systematic review and meta-analysis. , Principles and Practice of Clinical Research: Vol. 6 No. 3 (2020): Principles and Practice of Clinical Research
Paulo E. P. Teixeira, PT, MSc, Laila Alawdah, MBBS, MPH, Hassan Adam Alhassan, MD, MPH, Matteo Guidetti, PT, MSc, Alberto Priori, MD, PhD, Stefania Papatheodorou, Felipe Fregni, MD, PhD, The Analgesic Effect of Transcranial Direct Current Stimulation (tDCS) combined with Physical Therapy on Common Musculoskeletal Conditions , Principles and Practice of Clinical Research: Vol. 6 No. 1 (2020): Principles and Practice of Clinical Research
Bassel Almarie, Paulo E. P. Teixeira, Kevin Pacheco-Barrios, Carlos Augusto Rossetti, Felipe Fregni, Editorial - The Use of Large Language Models in Science: Opportunities and Challenges , Principles and Practice of Clinical Research: Vol. 9 No. 1 (2023): Principles and Practice of Clinical Research
Rodrigo Pirmez, Lisa Beltre, Lourdes Grassi, Luis Fernando Gonzalez, Luma Simões, Marco Carneiro, Maria Laura Mourão, Murilo Fernandes, Sumaiah J. Alarfaj, Thyagarajan Subramanian, Wallace S.C. Padilha, Laura Daniela Hernandez, Juan Antonio Valverde Espinoza, Alejandro Rodriguez Camacho, Amanda Bresciani, Cecilia Lameirinhas Longo, Daniela Seelmann, Elvia Rosales, Guillermo Villamizar Rodríguez, Hamayle Saeed, Jorge Alejandro Torres Ríos, Jacopo Santambrogio, Jose Guillermo Betancourt-Villalobos, Felipe Fregni, When Authorship Becomes a Burden: Learning About Authorship Issues in Scientific Articles , Principles and Practice of Clinical Research: Vol. 9 No. 3 (2023): Principles and Practice of Clinical Research
Kevin Pacheco-Barrios, Alejandra Cardenas-Rojas, Paulo S. de Melo, Anna Marduy, Paola Gonzalez-Mego, Luis Castelo-Branco, Augusto J. Mendes, Karen Vásquez-Ávila, Paulo E. P. Teixeira, Anna Carolyna Lepesteur Gianlorenco, Felipe Fregni, Home-based transcranial direct current stimulation (tDCS) and motor imagery for phantom limb pain using statistical learning to predict treatment response: an open-label study protocol , Principles and Practice of Clinical Research: Vol. 7 No. 4 (2021): Principles and Practice of Clinical Research
Bianca Barros Parron Fernandes, Mustafa Reha Dodurgali, Carlos Augusto Rosseti, Kevin Pacheco-Barrios, Felipe Fregni, Editorial - The Secret Life of Retractions in Scientific Publications , Principles and Practice of Clinical Research: Vol. 9 No. 1 (2023): Principles and Practice of Clinical Research
Johnson Ho, Eric Slawka, Kevin Pacheco-Barrios, Alejandra Cardenas-Rojas, Luis Castelo-Branco, Felipe Fregni, The pros and cons of tDCS as a therapeutic tool in the rehabilitation of chronic pain , Principles and Practice of Clinical Research: Vol. 8 No. 2 (2022): Principles and Practice of Clinical Research
Haley Rafferty, Elisa Rocha, Paola Gonzalez-Mego, Clara Ramos, Mirret M El-Hagrassy, Muhammed E Gunduz, Elif Uygur-Kucukseymen, Hanan Zehry, Swapnali Chaudhari, Paulo EP Teixeira, Gleysson R Rosa, Ana L Zaninotto, Christopher Connor, Uri Eden, Ciro Ramos-Estebanez, Felipe Fregni, Laura Dipietro, Timothy Wagner, Cost-Effectiveness Analysis to Inform Randomized Controlled Trial Design in Chronic Pain Research: Methods for Guiding Decisions on the Addition of a Run-In Period , Principles and Practice of Clinical Research: Vol. 8 No. 2 (2022): Principles and Practice of Clinical Research
Lucas Camargo, Alejandra Cardenas-Rojas, Daniela Martinez-Magallanes, Caroline Araujo, Felipe Fregni, Editorial: Enrollment and Adherence of Minorities in Clinical Trials for Chronic Pain , Principles and Practice of Clinical Research: Vol. 8 No. 4 (2022): Principles and Practice of Clinical Research

1 2 3 4 5 > >>

Article Sidebar

Main Article Content

Abstract

Article Details

How to Cite

Most read articles by the same author(s)