Breathing in the Future: Unraveling the Link Between Prenatal Outdoor Air Pollution and Neurodevelopment in Offspring: A Systematic Review

Main Article Content

Iana Malasevskaia
Sebastian Muñoz Nieto
Elsa Rueda-Borrero
Silvia Pereira Goulart
Maria Beatriz Bastos Lucchesi
Maria Carolina Fontana Antunes de Oliveira
Pedro Luiz Lage Bodour Danielian
Ahmed Shaaban
Juliana Perez Pinzon
André Silva Alves
Daniela Marín Araya
Julia Hansen
Augusto Cesar Villar de Almeida
Valentina Ferrer Valencia
Alain Freund
Mildred Tavarez
Ana Lucia Portilla
Abdelaziz Mohamed
Andrea Carolina Quintero
Zamar Anyela Malca Calderon
Termeh Jahanbakhsh
Carlos Montalván
Igmilka Dayana Milles Dommar
Yusuf Adelabu

Abstract




Introduction: Air pollution exposure has been associated with general negative effects on the nervous system and, consequently, on children’s neurodevelopment. This review aims to assess the main damages of prenatal air pollution exposure on the offspring’s neurodevelopment.


Methods: A systematic review was conducted using PubMed/Medline, Cochrane, Ovid, and Scopus. The studies from the last ten years were assessed in compliance with PRISMA 2020 Guidelines and evaluated regarding quality.


Results: From an initial 675 references, 24 observational studies encompassing 115,228 children aged 0 to 10 years were deemed eligible. On average, the women in the studies were around 30 years old at delivery. Various exposure assessment methods, pollutants, and neurodevelopmental outcome scales were utilized. All the studies included found an association between air pollutant exposure and neurodevelopment in different magnitudes. All 24 studies included in our review were observational and, therefore, assessed using the Newcastle-Ottawa Scale (NOS). Of them, 19 were considered good quality, 1 was fair quality, and 4 were poor quality.


Conclusion: This comprehensive review presents evidence suggesting that prenatal exposure to air pollution has a harmful impact on cognitive and neurological development in offspring. However, future studies are needed to corroborate these results.




Article Details

How to Cite
Breathing in the Future: Unraveling the Link Between Prenatal Outdoor Air Pollution and Neurodevelopment in Offspring: A Systematic Review. (2024). Principles and Practice of Clinical Research, 9(4). https://doi.org/10.21801/ppcrj.2023.94.6
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Author Biography

Iana Malasevskaia, Private Clinic of Obstetrics and Gynecology, Sana’a, Republic of Yemen

Private Clinic of Obstetrics and Gynecology, Republic of Yemen, Sana'a.

How to Cite

Breathing in the Future: Unraveling the Link Between Prenatal Outdoor Air Pollution and Neurodevelopment in Offspring: A Systematic Review. (2024). Principles and Practice of Clinical Research, 9(4). https://doi.org/10.21801/ppcrj.2023.94.6