Globalization has contributed significantly to the dissemination of information in different areas of knowledge. Scientific papers are therefore the way to contribute to this global debate and advance in science. 

PPCR will therefore contribute to disseminate the latest research and updates on clinical research.

PPCR aims to provide a medium for the publication of scientific articles of high quality, thus promoting the work and training of clinical researchers globally. 

This is a Free Open Access Journal, it is initially expected to be quarterly and open for new submissions.

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Professor Felipe Fregni, MD, PhD, MMSc, MPH.

Professor of Physical Medicine and Rehabilitation, Harvard Medical School
Professor of Epidemiology, Harvard T.H. Chan School of Public Health
Director, Principles and Practice of Clinical Research, ECPE, Harvard T.H. Chan School of Public Health
Director, Spaulding Neuromodulation Center, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School

Managing Editors

Paola Gonzalez-Mego, MD.

Spaulding Neuromodulation Center, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School


Kevin Pacheco-Barrios, MD, MSc.

Spaulding Neuromodulation Center, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School


Online ISSN: 2378-1890
Indexed in:
 License:   CC BY 4.0 
Copyright – Dustin Tyler Joyce

Vol. 7 No. 1 (2021): Early view

Published: 2021-03-30

HYP-FAST trial study protocol: a phase II, single-center, open-label RCT comparing the effect of early time-restricted feeding on blood pressure control versus standard of care in individuals with primary hypertension.

Dr Agustina Valentini, Dr Jose Eduardo Loyola, Dr. Joice Inglez, Dr Roseanne Ferreira, Dr Jonas Souza, Dr Juan Santana-Guerrero, Dr Daniela Yucuma, Dr Vitor Liutti, Dr Salma Abdelrahman, Dr Michelle Pirazzoli, Dr Nina Kaegi-Braun, Dr Hans Reyes, Islam Ahmed, Dr Hiba Elhiday, Dr Andrea Guimaraes, Dr Joel Oller, Mary Friend, Jessica Sanches, Alvaro Sierra Mencia, Dr Ariel Kann, Dr Michelle Rosa

Efficacy and Safety of Experimental versus Approved CAR T-cell Therapies in Large B-cell Lymphoma Using Matching Adjusted Indirect Comparisons: A Systematic Review and Meta-Analysis Protocol

Bayarmagnai Weinstein, Bogdan Muresan, Sara Solano, Antonio Vaz de Macedo, YoonJung Lee, GwangJin Kim, Cristina Camargo, YuChen Su, Gabriela M.Henriquez Luthje, YeSeul Ahn, David Carpenter

Study Protocol - Impact of Lactobacillus rhamnosus GG on Allergic Reactions and Gut Microbiota Composition in Children with Cow’s Milk Allergy

A Single-Center, Randomized, Double-Blinded, Placebo-Controlled, Phase II – MILK ALLERGY Trial

Natalia A. Rivera-Rincón, Paulo Sampaio de Melo, Juan C. Padilla-Ruiz, Laura T. Muñoz-Sandoval, Augusto Lio da Mota Gonçalves Filho, Danielle Maeda Ideriha, Henriette De La Garza, Brigida Aguerrevere Branger, Christian Oliver Conde Abeliuk, Paulo Rafael Atoche Zavaleta, Sauradeep Mitra

Effect of Low dose Naltrexone versus Naproxen Extended-release for Pain Relief in knee osteoarthritis, a Triple-blinded, Non-inferiority Phase II Randomized Controlled Trial (FREEDOM) - Study Protocol

Caio Cesar dos Santos Kasai, Carlos Jose Figueredo Alcala, Maria Isabel Jardim Pereira, Rosario del Carmen Almanzar Lora de Then, Flabia Tejada Castro, Iloba Gabriel Njokanma, Rafael Firmino Ballester, Ashraf Tahseen Basheer Hantouly, Renata Junqueira Moll Bernardes, Rodrigo Gomes Taboada, Bandar Ahmed Alghamdi, Flavia de Oliveira Lima, Mariana Gasparoto Pereira Valerio, Mauricio Fernando Silva Almeida Ribeiro, Blanca Talavera de la Esperanza, Thiago Tavares dos Santos, Viviane Morais Cunha Lima, Banan Khalid Ibrahim Ahmed Khalid, Danny Michell Conde Monroy, Bibiana Maryluz Romani, Elbi Eulogio Morla Baez, Merlin Marry Thomas, Julio Cesar Robledo Cabello, Luiz Carlos Sa Junior, Maria Jose Aguilera Chuchuca, Fathima Minisha, Devy Veryuska Quiroz Robladillo, Daniel Oswaldo Dávila-Rodríguez, Abdu Haseeb, Juan Carlos Silva Godínez

COVID-19 – The efficacy of the LEAF-mask measured by assessing the viral load of the mask's inner and outer surface used by nurses in ICUs compared to the N95: a phase II, multicenter, randomized, controlled, open-label, clinical trial protocol

Hans-Udo Richarz, Augusto J. Mendes, Sofia M. Hincapie Arias, Anna M. Santos Cury Marduy, Shobha A. Chottera, Omar F. Yanque Robles, Aline de Moura Brasil Matos, Augusto CM Gomes, Vanessa Henriques Carvalho, Patricia Bottamedi Ratto Guimaraes, Melissa S. Grigorescu Vlass, Angela H. Motoyama Caiado, Alejandra A. Boto, Enmanuel Rosario Diaz, Jose Colleti Junior, Natalia Chaves
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