Principles and Practice of Clinical Research

Welcome

Globalization has contributed significantly to the dissemination of information in different areas of knowledge. Scientific papers are therefore the way to contribute to this global debate and advance in science.

PPCR will therefore contribute to disseminate the latest research and updates on clinical research.

PPCR aims to provide a medium for the publication of scientific articles of high quality, thus promoting the work and training of clinical researchers globally.

This is a Free Open Access Journal, it is initially expected to be quarterly and open for new submissions.

Send your scientific article!

Check out the rules for submission. As the journal aims to be an international publication, all information and article submission should be formatted in English.

Regards,

Editor-in-Chief:

Professor Felipe Fregni MD, PhD, MMSc, MPH

Managing Editors:

Paola Gonzalez-Mego MD

Kevin Pacheco-Barrios MD, MSc

Online ISSN: 2378-1890

Metrics:
H-index - 3

Indexed in:
Google Scholar
Science Gate - https://www.sciencegate.app/source/1713572797

License: CC BY 4.0

Vol. 8 No. 3 (2022): Principles and Practice of Clinical Research

Published: 2022-12-02

Editorial: Bench to Bedside – the translation of intracortical inhibition marker to clinical practice

Danielle Carolina Pimenta, Daniel Lima, Eric Slawka, Kevin Pacheco-Barrios, Felipe Fregni

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Clinical and hemodynamic phenotype of BMPR2 variation carriers with pulmonary arterial hypertension: A systematic review and a call to action
Clinical and Hemodynamic Phenotype of BMPR2∆/PAH+ patients

David Rodriguez, Miguel A. Floran-Bautista, Ben M.W. Illigens, Tiago Lemos Cerqueira, Alicia Ramirez-Rivera, Carlos Jerjes-Sanchez

49 - 59

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Efficacy and safety of over-the-scope clips® com-pared to through-the-scope clips for initial bleeding control in non-variceal upper gastrointestinal bleeding: a multicenter randomized clinical trial

Flávia Lopes, Maria Simon, Daniela Masoli, Carla Mori, Rachel Lima, Erlon Abreu-Silva, Shajahan Idayathulla, Stefano Monfrini, Nicolás Cáceres, Muhammad Umair Khan

1-9

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Effectiveness of an mHealth App as an add-on for Smoking Cessation in One year: A multicenter and randomized Trial (The MASCOT study)

Tatiana Gomez Gomez, MD, Inia Andrea Perez Villa, MD, Oluwatosin Zainab Omoyiola, MBChB,FMCPath, Gabriela Harumi Harano, Bpharm, Kaytiussia Raulino de Sena , Deusdedit Brandão Neto, MD, Alexandra Maria Rojas Amaris, MD, Fernando Andres Terry Escalante, MD, Yasmin Chimoni Pinto, Bpharm, Geraldine Olivia M. Martens, PT, P.hD., Rene Efrain Flores Cardenas, MD, Cesar Augusto Rangel Junior, MD, Naomi Vidal Ferreira, P.hD., Javier Ardebol Cook, MD, Fleming Mathew, MBBS, Daniel Menezes de Oliveira Lima, MD, Javed Iqbal, BS Nursing, MHA, Geethiikha Jammula, MBBS, Barbara da Camara Santos Marinho, MBBS, Thiago Ramos Grigio, MD, MSc, Vinicius Caldeira Quintao, MD MSc , Carla Graziella Queiroga de Souza, B.Sc., Maria Cecília de Carvalho Bortoletto, MD, Rui Nakamur, MD

60 - 67

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A randomized, double-blind, placebo-controlled, Phase 1/2a trial protocol to assess the safety and efficacy of TAK-101 administered by microneedles in patients with celiac disease

Corrêa, JWN, Buffone, F, Shweiki, S, Cano, K, Guerra, GC, Príncipe-Meneses, FS, Coelho, DRA, Pestaña, MA, Garzon, JF, Zambrano, LI , La-Banca, V, Kim, YZ, Geraldo, BLSS, Sekhon, M, Cardoza, P, Maestri, A, Bansal, A, Abuhzaima, E, Martinez-Magallanes, D, Innocenzi, AM, Mushtaq, K

37 - 48

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Protective Effect of Surgical Masks versus N95 Respirator in Prevention of SARS-CoV-2 Contami-nation in Healthcare Professionals: Systematic Re-view Protocol

Roberta Lins Gonçalves, Taina C. P. Lopes, Sarah Almeida Cordeiro, Deborah Natiely Travassos Marques, Celsa da Silva Moura Souza, Edson de Oliveira Andrade, Erika Barbosa Camargo

10 - 18

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The ExCITE-BA Trial: Effects of physical activity plus behavioral activation on preserving cognitive function in elderly patients with mild cognitive im-pairment
Protocol for a randomized, controlled, phase II, parallel, single-blinded, superiority trial

Enrico Suriano, Jolanta Golec, Bassel Almarie, Marta P. Wiącek, Erica R. R. Sady, Dauris Rosario, Andrés Felipe Herrera Ortiz, Alejandra Pedrero, Marcia Harumy Yoshikawa, Rodrigo Sacchi de Freitas-Santos, Abeir Alimam, Jordan Bistafa Liu, Basma Mohamed, Adriana do Nascimento Martins, Julián Orlando Casallas Barrera, Rebeca Andrea Mora Matus

29 - 36

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Neuromuscular Electrical Stimulation (NMES) as an Add-on Therapy for the Improvement of Dyspnea in Patients with Post-Covid Syndrome: a Protocol for a Phase II Randomized, Non-Pharmacological Intervention-Controlled, Double-Blind Study.

Anusree Anil Kumar, Cristina Naqui Xicota, Anny Christina Chin, Julia De Conti Pelanda, Thiago De Oliveira Monaco, Lena Adbelhadi Abdelwahab Mohamed, Katia Adriana Varela Borges, Matias German Herrera, Sabrina Gonzalez Pina, Ricardo Xavier Noriega Espinoza, Mario Enrique Ochoa Prieto, Jose Manuel Orenday-Barraza, Monica Scarleth Paz Ramirez, Danielle Carolina Pimenta , Eliza Dalasso Ricardo, Ippolito Notarnicola, Aseel Abdulrahim Mohammed Sukik

19-28

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Efficacy of Cannabidiol Versus Ibuprofen in the Relief of Menstrual Pain in Females Living with Primary Dysmenorrhea
A phase II, Non-Inferiority trial

Haneesha Mohan, Ramón Romano, Ana Andersen, Enzo Vera, Jade Iwasaka-Neder, Alexandre Kajita, Cecilia de Sousa, Viviane Mendes, Minhong Huang, Israel Owoade, Aline de Azambuja, Paula Tilley, Franciely Guedes, Antonio Vaz de Macedo, Michelle Menon Miyake

68 - 76

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The KDEP Trial
Protocol for a phase II, multicenter, open label, randomized controlled trial to evaluate the efficacy of ketogenic diet for symptomatic improvement of moderate to severe Major Depressive Disorder

Gargi Kakani, Taysa Litaiff Isper Abrahim Alves, Fateen Ata, Cesar Campos-Cuellar, Danny Jose Arias Diaz, Wilton Francisco Gomes, João Victor Mota Parente, Mona Wanda Schmidt, Natalia Lourdes Serrano, Alessia Kitleng Tay, Ram Vasudevan-Nampoothiri, Augusto Alves Pinho Vieira

77 - 83

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The HABIT: Heparin and Aspirin on Birth in Inherited Thrombophilia, an International Multicenter Phase IIb Randomized Triple Blinded Clinical Trial

Alessandra Carvalho, Camila Awad, Alessia Gallucci, Ana Paula Flores, Anibal La Riva, Daniel Díaz-Gil, Deivid da Silva, Taylor J Saraceno, Oswaldo Rivera, Stephan Fricke, Regina Garcia, Steven Zhou, Maria Bazan, Maria Castellaro, Luiza Alencar, Pedro López-Blanco, Eliluane Teixeira, Roberta Gonçalves, Priscila Etchebehere, Jessica Gonzalez, Tasneem Abdallah, Malaz Hamad Darmood, Shiema Ahmed, Paola Mendez, Saif Faisal, Devy Robladillo, Judith Gutierrez, Metteo Guidetti , Nebal Hussein

84 - 91

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