Background: Skin microcirculation is routinely used to assess systemic endothelial function. The advantages of this exam are; low cost, a noninvasive good predictor for cardiovascular diseases, and a valuable intermediate endpoint to assess cardiovascular therapies. Because some skin particularities such as age, dermatological diseases, it is desirable to review these points to understand better some exam variations.

Aim: This review aimed to discuss skin anatomical characteristics, and skin conditions that can influence endothelial function interpretation.

Key-Words : skin, endothelium, aging, connective tissue, vascular resistance.