Vitamin D Supplementation for the Prevention of Recurrent Urinary Tract Infection in Women - PROUD: A Randomized Controlled Trial

M. Irene Rodriguez-Sanchez; J.Fernando Camacho-Palma; Cristina Dominguez-Bellini; Bianca Susanna; Fernanda Oliveira de Andrade Lopes; Aashish Gupta; Arthur Accioly Rosa; Asako Gondo-Hirano; Bakytgul Yermekbayeva; Carola Kunath; Caroline Nishikawa; Christine Pinto; Débora Krieger; Gabriel Penteado; Juliana Stefanello; Luis Miguel Brenes; Luis Roberto Alvarez Contreras; Marcos Bento; Mariana Garcia; Marilena Nakaguma; Mayuko Kanayama; Ming Han Lincoln Liow; Nathalia Reis; Nelson Mizumoto; Ricardo Pinto; Samuel Shitara; Takehiro Niitsu; Vitor Vasconcellos

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Published: Mar 15, 2016

M. Irene Rodriguez-Sanchez

J.Fernando Camacho-Palma

Cristina Dominguez-Bellini

Bianca Susanna

Fernanda Oliveira de Andrade Lopes

Aashish Gupta

Arthur Accioly Rosa

Asako Gondo-Hirano

Bakytgul Yermekbayeva

Carola Kunath

Caroline Nishikawa

Christine Pinto

Débora Krieger

Gabriel Penteado

Juliana Stefanello

Luis Miguel Brenes

Luis Roberto Alvarez Contreras

Marcos Bento

Mariana Garcia

Marilena Nakaguma

Mayuko Kanayama

Ming Han Lincoln Liow

Nathalia Reis

Nelson Mizumoto

Ricardo Pinto

Samuel Shitara

Takehiro Niitsu

Vitor Vasconcellos

Abstract

Urinary tract infection (UTI) due to Escherichia Coli is considered the most commonly acquired bacterial infection in women. Currently used treatments for UTI prevention have conflicting evidence regarding efficacy. There is minimum information regarding the use of Vitamin D and its effect on modulating the innate and adaptive immune system, favoring the production of endogenous antimicrobial peptides such as Cathelicidin. It has been suggested that inducing Cathelicidin in the bladder is a potential complement in preventing UTI. This clinical trial aims at testing the use of Vitamin D in women diagnosed with recurrent UTI due to Escherichia Coli for its prevention. This will be a randomized, double blind controlled trial, with a multicenter approach.
Key-Words: Urinary Tract Infection (UTI); Women; Prophylactic Antibiotic; Vitamin D; Placebo.

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Vitamin D Supplementation for the Prevention of Recurrent Urinary Tract Infection in Women - PROUD: A Randomized Controlled Trial. (2016). Principles and Practice of Clinical Research, 2(1). https://journal.ppcr.org/index.php/ppcrjournal/article/view/29

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Vol. 2 No. 1 (2016): Principles and Practice of Clinical Research

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Clinical Research Design

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