Vitamin D Supplementation for the Prevention of Recurrent Urinary Tract Infection in Women - PROUD: A Randomized Controlled Trial

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M. Irene Rodriguez-Sanchez
J.Fernando Camacho-Palma
Cristina Dominguez-Bellini
Bianca Susanna
Fernanda Oliveira de Andrade Lopes
Aashish Gupta
Arthur Accioly Rosa
Asako Gondo-Hirano
Bakytgul Yermekbayeva
Carola Kunath
Caroline Nishikawa
Christine Pinto
Débora Krieger
Gabriel Penteado
Juliana Stefanello
Luis Miguel Brenes
Luis Roberto Alvarez Contreras
Marcos Bento
Mariana Garcia
Marilena Nakaguma
Mayuko Kanayama
Ming Han Lincoln Liow
Nathalia Reis
Nelson Mizumoto
Ricardo Pinto
Samuel Shitara
Takehiro Niitsu
Vitor Vasconcellos

Abstract

Urinary tract infection (UTI) due to Escherichia Coli is considered the most commonly acquired bacterial infection in women. Currently used treatments for UTI prevention have conflicting evidence regarding efficacy. There is minimum information regarding the use of Vitamin D and its effect on modulating the innate and adaptive immune system, favoring the production of endogenous antimicrobial peptides such as Cathelicidin. It has been suggested that inducing Cathelicidin in the bladder is a potential complement in preventing UTI. This clinical trial aims at testing the use of Vitamin D in women diagnosed with recurrent UTI due to Escherichia Coli for its prevention. This will be a randomized, double blind controlled trial, with a multicenter approach.
Key-Words: Urinary Tract Infection (UTI); Women; Prophylactic Antibiotic; Vitamin D; Placebo.

Article Details

How to Cite
Rodriguez-Sanchez, M. I., Camacho-Palma, J., Dominguez-Bellini, C., Susanna, B., Oliveira de Andrade Lopes, F., Gupta, A., Accioly Rosa, A., Gondo-Hirano, A., Yermekbayeva, B., Kunath, C., Nishikawa, C., Pinto, C., Krieger, D., Penteado, G., Stefanello, J., Brenes, L. M., Alvarez Contreras, L. R., Bento, M., Garcia, M., Nakaguma, M., Kanayama, M., Lincoln Liow, M. H., Reis, N., Mizumoto, N., Pinto, R., Shitara, S., Niitsu, T., & Vasconcellos, V. (2016). Vitamin D Supplementation for the Prevention of Recurrent Urinary Tract Infection in Women - PROUD: A Randomized Controlled Trial. Principles and Practice of Clinical Research, 2(1). Retrieved from https://journal.ppcr.org/index.php/ppcrjournal/article/view/29
Section
Study Design

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